★★★★★
The consultation was clear, thoughtful, and never rushed.
Treatment
Polynucleotides
A regenerative injectable derived from purified DNA fragments that improves skin quality, hydration and elasticity from within.
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- 15 Years of Excellence
- Award Winning Clinic
- — trusted by 2,017 clients
Benefits of Polynucleotides
- Improves skin quality, elasticity and firmness
- Boosts hydration from within
- Particularly suited to the delicate under-eye area
- Supports natural repair and renewal
- Improves tired, thin or crepey skin
- Natural, gradual results
At a glance
Treatment duration30 min
Result lastsSeveral months with maintenance
Sessions required2–3 sessions
DowntimeNone
DriveSame day
ShowerSame day
SportWait 24 hours
Sexual activityNo restriction
★★★★★
The whole team made the process feel straightforward.
★★★★★
A professional and reassuring experience from the first enquiry.
★★★★★
I felt listened to and received balanced advice.
★★★★★
The clinic was welcoming, organised, and very clear.
How does Polynucleotides work
The polynucleotide gel is injected into or just beneath the skin across the treatment area. Once in place it supports the activity of skin cells and fibroblasts, encouraging repair, better hydration and gradual improvement in elasticity and firmness. Because it works by stimulating your own skin over time, results build across a course of sessions rather than appearing instantly.
Polynucleotides support the skin's own repair machinery:
- Cellular repair — provide building blocks that support skin cell renewal
- Fibroblast stimulation — encourage the cells that produce collagen and elastin
- Deep hydration — improve the skin's ability to hold moisture
- Anti-inflammatory action — help calm and improve the skin's overall environment
Patient Journey
What to expect
Consultation
Every treatment begins with a consultation. Your practitioner assesses your skin quality and concerns, discusses whether polynucleotides or another treatment best suits your goals, reviews your medical history including any allergies to fish, and agrees a course before proceeding.
Preparation
- Avoid alcohol for 24 hours before treatment
- Pause non-essential blood thinners for a few days where safe
- Tell your practitioner if you have a fish allergy, as the product is often fish-derived
- Arrive with clean skin, free of make-up
- Avoid other facial treatments in the days beforehand
Treatment
After cleansing and applying numbing cream, the polynucleotide product is injected across the treatment area using a fine needle, with a series of small injections placed evenly. You may feel brief pinches and mild pressure. The appointment usually takes around thirty minutes. Small bumps at the injection points are normal at first and settle within hours to a day. Aftercare advice is provided before you leave.
Downtime & Recovery
0–24 hours
Aftercare
- Avoid pressing or massaging the area for 24 hours
- Skip strenuous exercise, saunas and heat for 24 hours
- Avoid make-up for the rest of the day
- Keep the skin clean and use gentle products
- Apply SPF and avoid direct sun
- Complete the recommended course for the best results
Patient results
View Before & After Results
Explore real patient outcomes and see the considered results achieved across our treatments and procedures.
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Contraindications
- Pregnant or breastfeeding
- Known allergy to fish or to the product
- Active infection or inflammation at the site
- Certain autoimmune conditions
- Active skin infection such as a cold sore in the area
Risks and side effects
- Temporary swelling and redness
- Small bumps at the injection points that settle within hours to a day
- Bruising
- Tenderness in the treated area
- Rarely, infection or an allergic reaction
Polynucleotides
at Aurelia Clinic
Aurelia Clinic ManchesterAurelia Clinic London
Polynucleotides (single session) £300
Polynucleotides - Course of 3 £800
Who performs Polynucleotides
Frequently asked questions
Usually a course of two to three sessions spaced a few weeks apart, followed by occasional maintenance.
Filler adds volume, while polynucleotides improve the quality, hydration and elasticity of the skin itself. They can be used together.
Improvement builds gradually over several weeks as the skin repairs, with the best results after completing the course.
Yes, it is one of the most popular treatments for improving the quality of delicate, crepey under-eye skin.
Minimal, aside from small temporary bumps and possible minor bruising.
